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Mechanistically, GLP-1R activation appears to downregulate TNF- production via 1-adrenergic, -opioid, and -opioid receptor pathways (Wong et al., 2024)

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has received grants from Esteve and AstraZeneca and consultancy or speaker fees or travel support from AstraZeneca, Bayer, Menarini, Novo Nordisk, Boehringer Ingelheim, Amgen, Mundipharma and Lilly and is Editor for Nefroplus

8): Copper-catalyzed CArO coupling enables lipophilic modifications, enhancing membrane permeability while preserving synthetic feasibility [220]

Efficacy and safety of lubiprostone for the treatment of chronic idiopathic constipation: a phase 3, randomized, placebo-controlled study