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Microbial metabolites also affect anxiety, dysphoria, and stress reactivitycore drivers of craving and relapse

They concluded that the net price of Zepbound would have to come down by 31% and the net price of Wegovy would have to come down by 82% for these drugs to be cost-effective at $100,000 per QALY
Mitochondrial dysfunction, improper protein processing, and oxidative stress are direct consequences of metabolic abnormalities

27 The mean eGFR was 62 ml/min/1.73 m, and 76% of patients had NYHA class II symptoms
