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"For this particular outcome, the symptoms and physical limitations due to heart failure, it's the best results we've gotten with any medication in this type of heart failure so far today, Kosiborod said

The label on GLP-1 medications say they are to be used in combination with a reduced-calorie diet and increased physical activity, said Geoff Cook, Chief Executive Officer of Noom

Regulatory hurdles also pose a challenge, as companies must comply with strict FDA regulations regarding health claims associated with their products

That includes proactive management of side effects, candid conversations about the long-term nature of treatment, infrastructure to identify and support patients at risk of stopping and addressing the cost barriers that make GLP-1 therapy unsustainable for many. These measures are especially important, Al-Aly noted, because the cardiovascular protection provided by GLP-1 medication builds slowly, but it erodes quickly

[DOI] [PubMed] [Google Scholar] 685.Barker KB, Palekar NA, Bowers SP, et al