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Second, the reduced cellular energy expenditure occurring after weight loss achieved by an appetite-reducing drug may be balanced by the urinary caloric loss secondary to glucosuria [41]

Metabolism and physiology of enteroendocrine hormones Centers on the degradation and metabolism of the entero-pancreatic hormones (GLP-1, GLP-2, GIP, PYY, glucagon), the physiology and pathophysiology of the incretin hormones, and the therapeutic applications of the incretin hormones, GLP-1 analogues and DPP-4 inhibitors in the treatment of type 2 diabetes

On the other hand, new evidence has demonstrated that GLP-1 agonism also plays a key role in glial cells, thus, astrocytes in the NTS (solitary nucleus) could regulate the central effects of GLP-1 controlling the energy balance, as demonstrated by the pharmacological inhibition of NTS astrocytes attenuating the anorectic and body-weight-suppressive effects on intra-NTS GLP-1R activation [103]

Many patients with obesity are now managing their condition with a primarily pharmacological approach

- [22]
