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While crowded discs may increase the baseline risk for optic nerve events, there is no direct evidence that having crowded optic discs increases a medication-specific risk with semaglutide

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Clinical Evidence and Expected Weight Loss Outcomes FDA-Approved Semaglutide Trial Data Clinical trial data for FDA-approved semaglutide provides context for expected outcomes: The STEP 1 trial showed an average weight loss of approximately 14.9% over 68 weeks when combined with reduced-calorie diets and increased physical activity

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Reasons to Pause or Stop GLP-1 Therapy GLP-1 therapy helps with weight loss

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J Diabetes Investig 1:823 Samms RJ, Coghlan MP, Sloop KW (2020) How may gip enhance the therapeutic efficacy of GLP-1

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