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They were originally created to help treat type 2 diabetes but are now also being used as a weight management drug

World Journal of Diabetes, 12 (5), 616

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Risk factors include female gender, increased age, cardiovascular disease, diabetes mellitus, constipation, irritable bowel syndrome, thrombophilia, history of abdominal aortic aneurysm repair, constipation-inducing drugs, immunomodulators, and other illicit drug use [1,2,3]

Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly