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Increased intracellular Ca2+ concentrations trigger fusion of insulin-containing granules with the plasma membrane and insulin secretion from the cells

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This general gut microbial profile, including a higher Firmicutes : Bacteroidetes ratio, is in agreement with previous reports in high-fat diet fed mice 9,63,64 and obese humans 5,6,65,66

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54 Cucurmin, a potential natural plant drug that shows lipid-modifying, antioxidant, and anti-inflammatory effects, has demonstrated potential benefits for MAFLD