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Muscle Loss Risk Increases (Major Concern) GLP-1 users already risk: low protein intake low calorie intake rapid weight loss lean tissue loss Add nightly alcohol and you get: impaired muscle protein synthesis lower testosterone (men) reduced growth hormone increased cortisol reduced recovery Result: More muscle loss Less fat loss Softer look Slower metabolism This is one of the biggest physiological downsides

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Furthermore, exaggerated postprandial GLP-1 response is believed to contribute to the increased satiety reported by many gastric-bypass surgery patients (9496)

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WMD = 2.30 kg, 95% CI 0.53 to 4.07, P = 0.01, 2 = 0.0%

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In fact, glucagon has been shown to slow gastric emptying and inhibit GI motility [1]

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