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Cardiovascular and Endothelial Benefits GLP-1 RAs have demonstrated robust cardiovascular protection in multiple large-scale trials, including LEADER, REWIND, and SUSTAIN-6, showing reduced rates of major adverse cardiac events independent of weight loss

GLP-1R can also couple with adenyl cyclase using other G s subtypes such as G i and G q [44, 45]

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Most patients experience significant weight regain after discontinuation, and the long-term cost can become substantial
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