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Pharmacological effects of GIP, GLP-1 and their mimetics The pharmacological benefits of GIP, GLP-1, and their synthetic mimetics arise from their pleiotropic effects, encompassing at least five key functions: bolstering insulin secretion and survival of pancreatic -cells and modulating glucagon release by the pancreatic -cells in response to glycemic levels, acting on the satiety center in brain, slowing gastric emptying, regulating lipid and glucose metabolism through effects on adipose tissue and liver, and reducing systemic blood pressure

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GLP-1 use was not linked to increased risk for poor postoperative outcomes

Updated: As of late Nov

In addition, rare post-marketing reports of exenatide, liraglutide, and lixisenatide have been described for pruritus, urticaria, and angioneurotic edema