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That said, DEXA is certainly imperfect in splicing the details of this body composition change as adipose tissue includes plenty of lean mass. Additionally, the placebo group lost more lean mass (-1.83kg) than fat mass (1.37kg), which shows potential error. Nadolsky pointed out that rapid weight loss, in general, will reduce resting metabolic rate to some degree

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Semaglutide injections have been shown to offer multiple benefits, including significant blood sugar reduction, enhanced insulin sensitivity, reduced risk of cardiovascular events, substantial weight loss, and improved body composition

doi: 10.1152/ajpendo.00503.2002

These outcomes matter for long-term health and mortality and should not be overshadowed by aesthetic or weight-loss narratives