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Description
Approaches for targeting p53 can be summarized as follows: first, compounds such as idasanutlin (RG7388) and RG7112 were developed to prevent degradation of wild-type p53 by blocking p53-MDM2 interactions, 369,370 thus maintaining their ability to suppress tumor formation
The animals were housed in polycarbonate cages on racks within a climate-controlled room
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Conservative titration protocol This approach prioritizes comfort and minimal side effects above all else
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