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Guo M, Gu J, Teng F, Chen J, Ma X, Chen Q, et al
In contrast, a study comparing nateglinide with metformin demonstrated that metformin was more effective in lowering A1c levels (45)

doi:10.3390/biom13061002 135

The researchers found that the ingredient and manufacturing costs were a tiny fraction of the total price for all the drugs they investigated

Other reasons associated with poor glycemic control include physicians' lack of knowledge about diabetes treatment guidelines or their choice not to follow them
