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Description
This once weekly subcutaneous injection activates both incretin receptors, producing additive effects that surpass single receptor approaches
That said, when we attempt to pharmacologically interfere with, preserve, or augment the bodys innate physiological processes, there are bound to be side effects and adverse events
These effects create downstream changes in the liver
The administration of semaglutide to HFpEF models resulted in an increase in cardiac ATP production that led to an improvement in heart contractility [11]
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Moreover, SGLT2is are more beneficial in patients with HF and kidney disease
