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Findings In this cohort study of 16 058 patients (14 606 without and 1452 with cirrhosis), GLP-1 RA use was associated with a statistically significant reduction in the risk of progression to cirrhosis and its complications in patients with MASLD and diabetes than use of an active comparator treatment

Additionally, those on blood pressure medications should exercise caution

In March, popular weight loss program WeightWatchers acquired telehealth platform Sequence and announced members would be able to use the new subscription-based acquisition to get GLP-1 weight loss medications like Ozempic, Wegovy, and tablet options like Rybelsus

Patients should be counselled to respond promptly to the urge to defecate rather than delaying, avoid straining or spending excessive time on the toilet, and consider using a footstool to elevate the knees above hip level, which facilitates easier bowel movements