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Differences in clinical outcomes likely reflect variations in receptor potency ratios, pharmacokinetic profiles, dosing, and trial design rather than fundamentally different pharmacology

These mechanisms may accelerate the pharmacokinetic changes in the affected drug and lead to clinically relevant DDIs, particularly in drugs with a narrow therapeutic window

Twelve-week treatment with liraglutide as add-on to insulin in normal-weight patients with poorly controlled type 1 diabetes: A randomized, placebo-controlled, double-blind parallel study

Orskov C, Poulsen SS, Mller M, Holst JJ

Fourth, to assess the influence of unmeasured confounding, the E value was calculated based on the estimated HR for DR [30]