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77 Proposed mechanisms underlying this association include rapid weight loss, reduced gallbladder motility, or alterations in bile composition, although casaulity remains uncertain

During 2024 and 2025, the GLP-1 class was increasingly defined by expanded use cases and approvals, with existing drugs gaining indications including cardiovascular risk, sleep apnea and kidney disease

Oral Contraceptives: Tirzepatide (Zepbound/Mounjaro) may reduce efficacy due to slowed gastric emptying, especially during initiation and escalation

Understanding these mechanisms can help patients and healthcare professionals identify the underlying cause of sleep disturbances

Regular physical activity, adequate nutrition, consistent sleep and social support can all contribute to maintaining energy and motivation during weight loss