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Osteocalcin and irisin occupy an intermediate category, where strong preclinical biology contrasts with heterogeneous human data

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169 Ghrelin also mediates insulinostatic actions even though human beta-cells do not express any known receptors for ghrelin, but a recent study discovered that the ghrelin receptor is expressed solely by delta-cells, implying that ghrelin dampens insulin secretion by inducing somatostatin release