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Of note, the hindbrain GCG + neurons lack the GLP-1 receptor such that they cannot be directly activated by peripherally-derived GLP-1 [351]

PMID: 64 JastreboffA

Whilst high-fibre and high-protein foods can support natural GLP-1 production, the magnitude of effect is substantially smaller than licensed medications such as semaglutide or liraglutide

Ozempic ( semaglutide ) and metformin are both medications prescribed to help people with type 2 diabetes manage their blood sugar levels

Regulatory bodies may require a dedicated cardiovascular outcomes trial before or after full approval is granted consistent with the precedent set for other agents in this class though the precise regulatory requirements will be determined by the MHRA and EMA based on the totality of evidence submitted