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Tachyphylaxis and Duration of Effects A key feature of gastric effects associated with GLP-1 RA is the phenomenon of tachyphylaxis, where the gastric emptying effects diminish over time with continuous exposure lasting 8 to 24 h [18]
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Additionally, they lead to a dysregulation of Pancreatic Stellate Cells and Tumor-associated Macrophages, which subsequently leads to the fibrosis, cellular proliferation, apoptosis inhibition, and hyperplasia that is seen in pancreatic cancer [24,25]
