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Keywords: Stroke, type 2 diabetes mellitus, glucagon-like peptide 1 receptor agonists, cerebrovascular circulation, neuroprotection Key messages GLP-1 receptor agonist (GLP-1RA) therapy should be incorporated into a broad approach for risk reduction for stroke in patients with type 2 DM, especially in situations where prevention of ischaemic stroke is of high importance

Gradual dose titration, as recommended in the Summary of Product Characteristics (SmPC), significantly reduces the severity of gastrointestinal side effects