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Semaglutide manufacturers note that animal studies show excretion into milk, but human lactation studies have not been completed

Semaglutide and tirzepatide are large peptide molecules with molecular weights exceeding 4,000 daltons, a threshold that typically prevents significant transfer into breast milk

If 500 mcg EOD is not producing noticeable effects after a reasonable trial period: Increase to 750 mcg EOD (22.5 units) If still insufficient, increase to 1 mg EOD (30 units) Wait 5 to 7 days between any dose changes to accurately assess your response before adjusting further Do not rush this phase

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doi: 10.1007/s13300-022-01218-y