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PlexusDx starts patients at 0.25mg weekly, increasing by 0.25mg every week until reaching the therapeutic maintenance dose of 1mg weekly

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Common side effects include nausea, vomiting, and stomach discomfort

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Some argue that GLP-1RAs may exert neuroprotective effects indirectly via systemic mechanisms, while others suggest that more brain-penetrant incretins might be required for meaningful benefit