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Alternative Weight Management Options if Saxenda Isn't Working If Saxenda fails to produce adequate appetite suppression or weight loss after 12 weeks at the maintenance dose (defined by NICE as less than 5% body weight loss), your clinician should review your treatment plan and consider alternative approaches

Dal Molin M, Kim H, Blackford A, Sharma R, Goggins M

For patients without specific cardiovascular risk factors, baseline vital signs including heart rate should be documented before initiating tirzepatide, with routine monitoring at follow-up visits as part of standard care

The weight maintenance guide covers this transition in detail
