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Patients with proliferative retinopathy or maculopathy resulting in active treatment were excluded from the PIONEER 6 CVOT, in which no apparent imbalance was observed between oral semaglutide and placebo in the AE reporting of diabetic retinopathy over 16 months (66)

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This typically involves taking a thorough medical history, laboratory tests, and a physical examination for signs of obesity or overweight and associated complications

All GLP-1 agonists labeled for weight reduction in cases of obesity or overweight plus one weight-related comorbidity must be combined with a reduced-calorie diet and increased physical activity