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The most relevant factor is its well-tolerated ability

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8.4%, p=0.61)

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Standard titration schedule The clinical titration protocol for tirzepatide follows a monthly escalation pattern designed to minimize gastrointestinal side effects

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Many patients continue metformin for its additional metabolic benefits and lower cost

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In the TRIUMPH-1 Phase 3 trial, participants experienced up to 28.3% weight loss over 80 weeks

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