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Simple Comparison between upcoming Monthly GLP-1s: By Amgen and Pfizer The Monthly Obesity Treatment Race Is Heating Up The next wave of obesity pharmacotherapy may not be about achieving greater efficacy aloneit may also be about achieving it with less frequent dosing

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But human observational evidence is increasingly reassuring on major malformations when confounding is handled carefullyfor example, large datasets show no substantial increased risk of major congenital malformations with early exposure, and a European teratology cohort reported no increase in major birth defects vs diabetes/high-BMI comparators