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It does note important safety considerations including potential worsening of diabetic retinopathy with rapid improvement in glucose control, and risks of pancreatitis and gallbladder disease

According to Pfizer, the enzymes returned to normal after the patient ceased taking danuglipron

A cross-sectional study of 2,691 Chinese men found that ex-smokers and heavy smokers (40 cigarettes/day) had a higher prevalence of MASLD than never-smokers and some studies have reported that smoking is an independent risk factor for MASLD, which may exacerbate MASLD (128,129)

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The MHRA issued a warning about the risk of acute pancreatitis in January, which is often linked to gallstones, a common side effect of GLP-1s