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They added that future studies with agent-specific exposure assessment and clinically adjudicated ophthalmic outcomes are needed to clarify whether the signals observed across recent studies reflect causal risk, residual confounding or differences in study design

It utilises a computer adaptive testing paradigm allowing assessments to be completed in 40 minutes

Other documented adverse effects include decreased appetite (which contributes to the therapeutic effect), fatigue, injection site reactions, dizziness, and modest increases in heart rate (typically 2-4 beats per minute)

doi: 10.1152/ajprenal.00082.2009 91 CrajoinasROOricchioFTPessoaTDPachecoBPLessaLMMalnicGet al

The tolerable upper intake level for adults is generally set at 4,000 IU daily from supplements, though short-term higher doses under medical supervision are used for correction of deficiency
