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Future research is crucial to investigate whether a washout period for GLP-1 agonists before CLN is needed to reduce the risk of AC, if such a risk exists.

Safety Considerations and Managing Risks GI Side Effects: Transient issues like nausea, vomiting, and diarrhoea are common, especially during initial dose escalation

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In real-world settings multiple factors contribute to non-persistence, including adverse effects, high cost-sharing and weight loss not meeting patients' expectations.
