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Extra fat cells act like mini chemical factories, releasing hormones and inflammatory messengers called cytokines, such as interleukin-6 (IL-6), Tumor necrosis factor alpha (TNF-alpha), interleukin-17 (IL-17), and others

The UK regulatory picture This is the part of the story most reviews skip, and it matters

Importantly, these responses could also be explained by the redundancy of insulinotropic signals from the gut or nervous system during oral versus IP glucose loads, but in the end still demonstrate that -cell GLP-1r, in and of themselves, are not necessary for oral glucose tolerance

However, the Cre + Ex mice showed no difference in -cell mass from Cre Ex controls at baseline (1.65 0.18 mg)

Both have been found to be associated with improved cognitive function due to their expression in brain tissue [2224]