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Sympathetic modulation Given the above-described role of SNS in the pathophysiology of obesity and its cardiovascular consequences, SNS inhibition is considered a potential therapeutic target in obesity

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Van Gaal, M.D., Ph.D., Ildiko Lingvay, M.D., M.P.H., M.S.C.S., Barbara M

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Another protective mechanism exerted by exenatide on the endothelium is through its action through opening the KATP channels thus protecting against impairment in endothelium-dependent vasodilatation induced by ischemiareperfusion (IR) injury [64]