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Agent-level network meta-analysis Major adverse cardiovascular events In the agent-level NMA, tirzepatide significantly reduced the risk of MACE compared with placebo (HR 0.81, 95% CI 0.700.94) and with lixisenatide (HR 0.79, 95% CI 0.650.97)
doi:10.1111/bph.13384 46
The honest boundaries: these trials studied specific, supervised patient populations with clinical monitoring
