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PMC12411320 Pangea Wellness Inc

Treating hypogonadism Hypogonadism, where the body produces insufficient testosterone, affects millions of men

Electronic databases including PubMed, Embase, and Web of Science were searched from inception until August 2025 using keywords such as GLP-1 receptor agonist, diabetic retinopathy, glaucoma, age-related macular degeneration, ocular disease, and neuroprotection. The search focused on identifying preclinical studies, large-scale retrospective cohort studies, and post-hoc analyses of major clinical trials that evaluated the utility and potential mechanisms of GLP-1RAs in ophthalmic diseases

The useful observation in this window is simple tolerability whether the chosen route is comfortable and consistent

While steady-state levels are reached within 4 to 5 weeks, clinical effectiveness can vary from person to person