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p = 0.022), especially in patients at high CV risk (age 65 years, T2D duration 10 years and BMI 30 kg/m 2 ), but not the other DPP-4is, suggesting a differential effect of each DPP-4 inhibitor on the risk of HF [151]

264,269 Furthermore, GLP-1 can slow down gastric emptying by activating the vagus nerve, a part of the autonomic nervous system crucial for regulating the activities of the gastrointestinal tract

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Rather than feeling medicated or altered, most people report that their baseline emotional state improves

This discrepancy between formal trial data and patient-reported experiences may reflect several factors: cold sensitivity might not have been specifically monitored in trials, it may be attributed to weight loss rather than the medication, or it might affect only a subset of patients