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In human monocytes GLP-1 is strongly detectable, with waning after differentiation into macrophages ( The potential relationship between anti-inflammatory effects of GLP-1 and CAD is shown in Figure 1
However, many anti-obesity agents that have entered human clinical trials have shown unacceptable adverse events
Schauer IE, Snell-Bergeon JK, Bergman BC, Maahs DM, Kretowski A, Eckel RH, et al
Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I736 amide in type I diabetic patients
Meng, J
