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Observations in rodent models include changes in metabolic biomarkers, hepatic lipid levels, and gene expression patterns related to energy metabolism [5]

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If all three laboratories return consistent purity numbers, that provides substantially stronger evidence than a single test from a single lab

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consider Metformin dose reduction if A1C below 6.5% Week 24+: If A1C stable below 6.0%, consider further Metformin reduction with close monitoring The additive effects of combination therapy were suggested by the trial subgroup analyses