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PlexusDx's Precision Peptide Genetic Test reveals predispositions in key peptide-signaling variants (GLP1R rs6923761, GIPR rs1800437, FTO rs9939609, MC4R rs17782313) that may help provide context for treatment planning

10.1677/joe.0.1760133

62,63 In the pancreas, this pathway boosts insulin release in response to rising blood glucose, helping to keep glucose levels stable

However, the net outcome of central stimulation leads to more prominent reductions in appetite, blood glucose and body weight in adult females, suggesting that GLP-1 receptor treatments are more effective treatments for diabetes and obesity in females compared to males