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The European Medicines Agencys 2025 synthetic peptide quality guideline treats peptide-related impurities as first-class critical quality attributes: deletion and truncated sequences, dimers, oligomers, and degradation products each need characterization, with European Pharmacopoeia practice pointing to reporting thresholds at 0.1% and identification thresholds above 0.5% for peptide-related impurities in pharmaceutical use

For those with significant obesity, referral to a Tier 3 specialist weight-management service or, where clinically appropriate, consideration of bariatric surgery under Tier 4 criteria may be appropriate

Clin Drug Investig 2022;42(11):965975

Shortening this interval increases peak drug concentration and the risk of gastrointestinal side effects

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