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Other common adverse effects include injection site reactions, headache, and nasopharyngitis, but these effects do not usually result in discontinuation of the drug

doi: 10.2147/OTT.S150701 75 AkiyamaSOgiwaraTAokiTTsunekawaKArakiOMurakamiM

Several research studies with rodents fed a high-fat diet, different animal models of obesity and diabetes, and patients diagnosed with T2DM have all shown changes in gut microbiota caused by metformin, as shown in Table 1

Morgan Global Research, 29 Nov

Following comprehensive evaluations in 20132014, both agencies concluded that available evidence did not support a causal association between these medications and pancreatic cancer