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Both medications are injectable GLP-1 receptor agonists used for type 2 diabetes management and weight loss, but they have several important differences: Mounjaro (tirzepatide) : Functions as both a GIP and GLP-1 receptor agonist, targeting two hormone pathways Ozempic (semaglutide) : Works solely as a GLP-1 receptor agonist, targeting one hormone pathway Based on the Phase 3 SURPASS-2 clinical study: Mounjaro : Approved for type 2 diabetes Ozempic : Approved for: Mounjaro : Ozempic : For expats and travelers in Mexico, both medications require a prescription, but Mounjaro may be preferred by those seeking more significant weight loss or better glycemic control

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In support of this hypothesis, deletion of the glucagon gene in both proximal and distal Lcells in mice abolished both the early and late phases of nutrientinduced GLP1 secretion