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Clinical trials show that about 85 to 90 percent of participants lose at least 5 percent of their body weight, which is considered clinically significant weight loss

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Evolutionarily, we were designed to eat as much and as fast as we can, because there was no way to preserve food. Extra calories are stored as fat, but as soon as you start losing weight, your body starts thinking somethings wrong, Suri explains, which, hormonally, makes it harder to lose weight. The body responds by increasing appetite and slowing metabolism, and the hormones that regulate feelings of hunger kick into high gear, to drive your body weight back to the set-point range. GLP-1s and GIPs help override those hunger signals while improving the insulin receptivity that allows your body to burn fat