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Any consideration of dual therapy requires baseline cardiovascular assessment, including blood pressure monitoring, ECG if indicated, and ongoing cardiac surveillance

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In contrast, PF animals were provided with a fixed amount of food based on their matched SEMA pair's intake, without free access to the two diet types, to ensure intake of HFD and chow was matched to the SEMA group

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35 GLP-1 secreted from the gut is also likely to be a physiological regulator of appetite and food intake