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Helpful strategies: Start the day with protein-rich meals Avoid late-night eating Maintain consistent meal timing Some patients benefit from time-restricted eating, which may enhance GLP-1 release

It is well known that metformin primarily inhibits hepatic gluconeogenesis and improves insulin action on muscle and adipose tissue to lower high blood glucose 45,46

[9] [10] When substantial weight loss occurs, these hormonal balances shift, potentially leading to temporary menstrual irregularities

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