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Monoamine oxidase (MAOA) is an enzyme involved in the metabolism of neurotransmitters, so altering MAO levels can have an anti-depressive effect on some people.[ref][ref] Related article: MAO-A and MAO-B: Neurotransmitter levels, genetics, and studies 3) Alzheimers studies: In animal studies, methylene blue shows efficacy in Alzheimers disease