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Co-treatment of GLP-1 RAs and AP-5 also had no effect on food intake or body weight.Reference Mietlicki-Baase, Ortinski and Reiner 37 Taken together, the aforementioned triangulation of evidence indicates that GLP-1 RA-induced suppression of food intake and effects on body weight may be mediated through AMPA/kainate receptor signaling but not NMDA receptors