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EClinicalMedicine 2021;42:101213

GLP-1RAs thus prevent the occurrence of retinal damage associated with oxidative-stress-induced activation of glial cells and collectively foster a healthy retinal microenvironment by virtue of preventing cellular overexertion [94, 100]

Systemic and intracerebroventricular administration of exendin-4 or even native GLP-1 in male rats increases HRs up to 600 bpm (nearly double rat resting HR) and blood pressure for several hours postadministration (28, 130, 131)

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Perhaps the best single paper on this topic comes from Oprea and colleagues and was published in the British Journal of Anaesthesia in July 2025