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It seems likely that more selective antagonists with optimized pharmacokinetic profiles would advance our understanding of the importance of endogenous GLP-1 action

As the rise of GLP-1 weight-loss drugs begins to reshape not just waistlines, but the wider food economy, what started as a breakthrough treatment for obesity and diabetes is rapidly becoming a commoditised lifestyle trend, with implications stretching from supermarket shelves to British farmland

Life Sci 197:4655 Hidalgo Santiago JC, Maraver Delgado J, Cayn Blanco M, Lpez Saez JB, Gmez-Fernndez P (2020) Effect of dapagliflozin on arterial stiffness in patients with type 2 diabetes mellitus

Those who took GLP-1s for less than 18 months before discontinuing saw no significant risk reduction compared to the group on sulfonylureas at the end of the trial

The therapeutic benefits stem from weight reduction and decreased epicardial fat together with enhanced myocardial energy metabolism and reduced systemic inflammation [11]
