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In a combined analysis of subcutaneous (SUSTAIN-6) and oral [PIONEER 6 (NCT02692716)] T2DM CVOTs, semaglutide consistently reduced MACE risk versus placebo across all eGFR and urinary albumin:creatinine ratio (UACR) subgroups [58] Additionally, semaglutide (SELECT) reduced MACE in participants with overweight/obesity and baseline CVD but no T2DM [48]
The weight reduction aspect is a journey, sometimes a long one for some people and plateaus can occur but the glucose control seems to remain functional
As expected, the vast majority of water intake occurred during the 12-h dark phase
