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In isolated bladder strips obtained 8 or 12 weeks after the STZ injection, the Rac1 inhibitor NSC23766 (0.1, 1, and 10 M) attenuated carbachol-induced contraction in all groups, but the extent of inhibition was greater in the diabetic and insulin-treated than the nondiabetic rats (Evcim et al

Patientcentered considerations Eligibility and benefit must be weighed against individual comorbidities, preferences, and treatment burden

Preoperative planning is multidisciplinary, involving surgeon, anesthesia, cardiology, and ICU teams

What We Know So Far The study, published online February 3, 2026, was conducted by researchers at the University of Texas at San Antonio (UTSA) and the South Texas Poison Center
